Many USB to Serial adapters do not support all of the RS-232 control lines. We went through that headache years ago with the equipment I worked on. Any old adapter would work for normal text communications, but most would fail when the equipment (and PC software) shifted to a true high speed protocol that required all of the control lines, for updating the equipment firmware.
Through trial-and-error, we compiled a list of which adapters would work and only purchased those. Unfortunately that was so long ago, the list would be completely out of date today, even if I still had it.
Here is a detailed list of all the control lines, but I doubt it will be any help.
http://www.usconverters.com/index.php?main_page=page&id=61
@alpine1 - The pic you posted of the box for your adapter shows that it is indeed only using 3 pins. That is most likely your problem.
Here is a link to one that uses all of the lines: http://www.usconverters.com/usb-rs232-adapter-xs8801
Of course, I can’t guarantee this one will work in your setup, but it’s almost certain the one you’re using will never do what you need.
Before ordering, look at your adapter and make sure it has pins like the pic in the link to the one I provided.