I got my MiniPro yesterday and hooked it up and ran into the com port issue initially as well. Note that I’m using it not for the Brio2 but for the OPN1 but it shouldn’t be relevant in this discussion anyway, just throwing it out there for clarification just in case somebody wants to ask me about Brio2 programming and I know nothing about it.
I connected the MiniPro to a USB hub where I have 3 other hard drives also connected to the hub, and the hub is connected to a USB3 port on my laptop. My MiniPro initially came up assigned to com 6 according to my device manager. I changed it to com 1 which is available and it works just fine.
Just want to mention this to dispel the notion that connecting to a hub would be an issue.