Any tweaking you do after REM is moving off of prescription targets. The reason you want to have REM completed in the first place is to ensure you are at least meeting prescriptive targets and not just being dramatically underfit at one or all frequencies as is common with hearing aids that don’t have REM completed. It also ensures that the hearing aids are taking into acount your individual ear canal acoustics as well as the venting/coupling acoustics.
Prescriptive targets are the best AVERAGE settings we have come up with so far. Not everyone is average and so things may need to be tweaked, but keep in mind that the auditory system has often been deprived for a long time in advance of hearing aids and takes some time to re-adjust. Loud and moderate volume perception is also quite flexible (to a point), so things that sound loud at first may not sound loud over time. So you want to make sure you’re meeting prescriptive targets to start and then make sure you are giving your brain that time to adjust before deviating too far off of target, particularly by turning things DOWN. Tweak upwards at will with the exception of the MPO, which you should leave alone after the audiologist sets it.
Just save the entire fitting so that you can roll back to it if necessary.
If you’re in Oticon hearing aids and your audiologist is friendly, you could ask for a program set to NAL-NL2 targets AND a program set to DSL 5.0 Adult targets, and then you’d have both and could see what you liked.